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Because both peptides work through different receptors and different intracellular cascades , and the ghrelin arm additionally abolishes somatostatin inhibition, simultaneous stimulation of both pathways produces an effect in the models greater than the sum of each individual’s actions — this is a synergy phenomenon described in the physiology of the somatotropic axis for pairs of a GHRH analogue and a ghrelin secretagogue

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Volume:8

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