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Most patients experience very little discomfort during IV therapy

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This has been demonstrated both in vitro studies using the THP-1 cell line treated with atorvastatin (0.1–20 μM), as well as in randomized blind endpoint clinical studies in hypercholesterolemia patients using simvastatin (40 mg) or simvastatin/ezetimibe (10/10 mg) (Moutzouri et al., 2012