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In addition, IHC for VEGF-A (Proteintech, Chicago, IL, USA) and CD34 (Proteintech, Chicago, IL, USA) were performed using the automated IHC system (Hoffman La-Roche Ltd., Basel, Switzerland)

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The implementation and development of global computational and experimental methods to map and explore the metalation status of the proteome, 62,160,184,968,969 i.e , metalloproteomics, 68,970 as well as workflows to better define the metal buffering components in cells, 119 promises novel insights into metalloregulation of cell biology and mechanisms of metallostasis from single cells to whole organisms in all kingdoms of life