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In a similar manner to CF, the inability to clear mucus through ciliary motion can induce a stress response which over-secretes mucin and leads to increased viscoelasticity of the mucus (Wijers et al., 2017)

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Also in humans, it was shown that TMA-utilizing archaea correlated positively with bacterial gene counts of TMA-production pathways and negatively with fecal TMA concentrations [40]