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These extensive viral protein interactions with host-specific cellular targets could trigger severe human metabolic reprogramming/dysregulation (HMRD), a rewiring of sugar-, amino acid-, lipid-, and nucleotide-metabolism(s), as well as altered or impaired bioenergetics, immune dysfunction, and redox imbalance in the body

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This iron, combined with inflammation, triggers ferroptosis in the already compromised oligodendrocytes, impairing remyelination and worsening neurodegeneration [101] (Figure 2)